To study the effect of Sanqi Jiangzhi Powder on lowing blood liquid of patients with hyperlipidemia and hepatic steatosis.Methods: Seventy-nine cases of hyperlipidemia combined with fatty liver treated in the hospital were selected and divided into observation group (40 cases) and control group (39 cases) by random number table method. Patients in the control group were treated by simvastatin cholesterol-lowering treatment, while patients in the observation group were additionally given Sanqi Jiangzhi Powder. Differences of clinical effect, lipid levels and B ultrasonic examination signs between the two groups were compared. Results: The efficacy rate of the observation group was significantly higher than that of the control group with a statistically significant difference (P<0.05). There was no statistically significant difference in TC, TG, LDL, HDL-C levels of patients of the two groups before the treatment (P>0.05), while TC, TG, LDL-C levels of all patients were significantly lower after treatment (P<0.05). HDL-C level was significantly higher (P<0.05) and TC, TG and LDL-C levels of the observation group were significantly lower than those of the control group (P<0.05). HDL-C level was significantly higher than that of the control group (P<0.05). The liver normal /reduced proportion and liver echo attenuation proportion of the observation group were significantly higher than those of the control group (P<0.05). Conclusion: Sanqi Jiangzhi Powder has significant effect of lowing blood liquid for patients with hyperlipidemia and fatty liver and significantly improve liver function, which is worthy of clinical popularization and application.