To observe the curative effect of Six-Ingredient Rehmannia Pill on the patients with kidney yin deficiency type senile osteoporosis and its influence on osteocalcin and bone mineral density. Methods:A total of 70 cases of the patients with kidney yin deficiency type senile osteoporosis in our hospital were randomly divided into the control group and the observation group, the control group had oral alendronate once a week, 70 mg each time, the observation group had Six-Ingredient Rehmannia Pill on the basis treatment of the control group, 1 pill at a time, twice a day. Both of the two groups had 28 days′ treatment, continuous six courses of treatment, osteocalcin and bone mineral density changes were detected before and after treatment. And quality of life scale (36-items short form health survey scale, SF-36) was adopted to evaluate the quality of live on the patients after treatment. Results:1) Eight dimensions of SF-36 scale scores in the observation group were significantly improved, compared with before treatment and the control group after the treatment, the differences were with significant statistical significance (P<0.01). 2) BMD of lumbar spine（L1-L4）, the femoral neck, and total hip of the two groups after treatment were statistical different compared with before treatment (P<0.05), bone mineral density of the observation group were much higher than the control group after treatment (P<0.05); T value in the control group and the observation group after treatment were significantly higher than before treatment (P<0.05), and the observation group were significantly higher than control group (P<0.05); 3) The peripheral blood concentration of osteocalcin raised significantly in the two groups after treatment, (P<0.05), the results in the observation group was significantly better than the control group (P<0.05). Conclusion:Six-Ingredient Rehmannia Pill can improve quality of life in the patients with kidney yin deficiency type osteoporosis, by the synthesis of bone mineral density and osteocalcin.