Professor Liu Shenlin, Vice-president of Jiangsu TCM association, is Jiangsu Provincial famous physician and prominent TCM cancer experts. Liu has rich experience in syndrome differentiation for pancreatic cancer and summarized its pathetical factors as dysfunction of spleen, dampness and heat in liver and gallbladder, qi stagnation in middle-Jiao, toxic stasis in liver and spleen. He emphasizes strengthening spleen to tonify qi, clearing heat and dispelling dampness to sooth liver and gallbladder, soothing liver to regulate qi so as to relieve pain, activating qi to eliminating blood stasis, and removing toxins to eliminating stasis and receives good results. This paper is to analyze Prof. Liu′s academic thoughts and experience in treating pancreatic cancer through two case studies for providing more references.