To summarize the clinical experience of Professor Cai Lianxiang in the treatment of infertility due to decreasing ovarian reserve from aspects of cause and mechanism of disease and clinical treatment characteristics. Professor Cai suggested that insufficient kidney essence and malnutrition of Chong and Ren channel were key to the pathogenesis, and the liver′s dysfunction in promoting the free movement of qi as well as impeded circulation of qi and the blood were important factors. The prior treatment was to nourish kidney essence and Chong Ren channel, combined with dispersing the depressed liver-qi, activating blood circulation and removing meridian obstruction, together with the medicine for external application of warming channel and activating blood circulation, which obtained positive clinical effect.