To observe the effect of sodium sulfonate A sulfonate injection on the expression of vascular endothelial growth factor(VEGF)in rats with acute myocardial ischemia / reperfusion injury.Methods:Sixteen healthy rats were randomly divided into two groups，ischemia / reperfusion group and Salvia miltiorrhiza group.The two rats were treated with 1% sodium sulfonateⅡ A sulfonate injection and sodium chloride injection from caudal vein.After fourteen days，rats underwent a 30 min left anterior descending coronary artery occlusion and a 30 min reperfusion.This process was repeated 3 times.Mycardial tissue and serum were assessed by Western blot，quantitative RT-PCR and assay kit.Results:The expression of FLK-1，FLK-1mRNA，HIF-1a，HIF-1amRNA，VEGF and VEGF-mRNA were increased.The activity of SOD and CAT were significantly enhanced，however the content of MDA was decreased compared with IR.The difference showed statistically significant(P<0.05).Conclusion:Sodium Sulfonate A Sulfonate may enhance the expression of VEGF and the activity of SOD.It has certain protective effects on rats with acute myocardial ischemia / reperfusion injury.