To investigate the effects of the 12-week moxa smoke intervention on urinary parameters in Wistar rats.Methods:An automatic dynamic exposure device was applied for whole-body mode exposure.The moxa smoke concentration was represented by shading rate (SR:x %).Forty-eight male Wister rats were randomly divided into 4 groups (n=12/group):three moxa smoke groups according smoke concentrations (L 0.4%,M 2.0% and H 15%) and one control group (C).Three moxa smoke groups were respectively 1,3,and 9 times the clinical concentration.The exposure lasted for 12 weeks (200 min/d and 5 d/week).After the exposure,urine samples were tested by uric dry chemical analysis method.Results:Compared with C group,no statistically differences in the color,SG,PRO,GLU,BLD,URO,BIL were found in smoke-exposed groups (P>0.05).Conclusion:The 12-week moxa smoke exposure induced no smoke-related toxicity on urinary parameters in male Wistar rats.