To investigate the effect of acupuncture combined with Pubescent Angelica and Taxillus Decoction in the treatment of knee osteoarthritis and its clinical effect on micro inflammatory index.Methods:Total 92 knee osteoarthritis patients were randomly divided into treatment group (n=46) and control group (n=46).The treatment group was treated by acupuncture combined with Pubescent Angelica and Taxillus Decoction,the control group western medicine.The course of treatment was 8 weeks in two groups.The total effective rate,the effective rate of the symptoms,the joint swelling index,joint tenderness index,and the level of inflammatory factors and adverse reactions during treatment were compared between the two groups before and after the treatment.Results:The total effective rate of the treatment group (93.48%) was higher than that of the control group (73.91%) (P<0.05); The total effective rate of symptoms in treatment group (95.65%) was higher than that of control group (71.74%) (P<0.05); The joint swelling index,joint tenderness index decreased significantly in the two groups after treatment (P<0.05); The joint swelling index,joint tenderness index in the treatment group were lower than those in the control group (P<0.05); The serum levels of IL-1β,IL-6 and hs-CRP decreased significantly after treatment in both two groups (P<0.05); The levels of serum IL-1β,IL-6 and hs-CRP in the treatment group were lower than those in the control group (P<0.05); The rate of adverse reaction in the treatment group was lower than that of the control group (P<0.05).Conclusion:Acupuncture and moxibustion combined with Angelica parasitic Decoction treatment is effective in knee osteoarthritis with significant reducing effect in serum IL-1β and IL-6,hs CRP level and improvement in the micro inflammatory state,which has the important research value.