To observe the curative effect of combined therapy of acupuncture with triple viable bacteria in the treatment of Parkinson′s depression. Methods:A total of 106 cases of Parkinson′s disease patients with depression in outpatient or Department of Neurology in our hospital from June 2013 to 2015 September were randomly selected, including 47 female cases, 61 male cases; age from 59～78, average age (71.51± 6.06). The patients were randomly divided into treatment group and control group, 53 cases in each group. The two groups were given the basis routine therapy, the treatment group also received acupuncture and Bifid Triple Viable and control group of Bifid Triple Viable. The treatment lasted for 8 weeks. The HAMD and UPDRS scores of the patients were compared and analyzed before and after the treatment. Results:After 8 weeks′ treatment, the effective rate of treatment group and the control group was 92.45% and 79.24% respectively and the HAMD and UPDRS scores showed different degrees of improvement, but the treatment group had significantly better results than the control group (P<0.05), especially in the HAMD score (P<0.05). Conclusion:Acupuncture combined with triple viable bacteria can effectively relieve the depression of patients with Parkinson.