Using Meta analysis of shuxuetong combine with α-lipoic acid clinical effect on treatment of diabetic peripheral neuropathy by systematic review.And the analysis of the results guides clinical medication options.Methods:“Diabetic neuropathy”，“α-lipoic acid” and “Shuxuetong” were adopted as the search terms for comprehensive search in databases.Meta analysis was applied for literature relevant to Shuxuetong combined with α-lipoic acid therapy and α-lipoic acid therapy in the treatment of diabetic peripheral neuropathy.Results:Six papers including 614 patients with diabetic peripheral neuropathy were analyzed and the valid rate of α-lipoic acid treatment group was significantly higher than that of the control group(RD=0.19，95%CI ［0.13,0.25］，P<0.01).Conclusion:Shuxuetong combine with α-lipoic acid，compared with single α-lipoic acid therapy may effectively relieve the symptoms of diabetic peripheral neuropathy.As issues existed in methodology for the selection of literature，authenticity of the results may be affected.Rigorous，large sample，multi-center，randomized，controlled clinical trial will be further designed to validate the study.