To explain the combination rules of medicinal for liver cirrhosis due to chronic hepatitis B collected in CNKI by traditional Chinese medicine (TCM) inheritance Platform System. Methods: The prescriptions used for liver cirrhosis due to chronic hepatitis B in CNKI were collected and input into the TCM inheritance Platform System. TCM inheritance Platform System was used to explore the combination rules of medicinal in prescriptions for liver cirrhosis resulting from chronic hepatitis B. Results: The combination rules of medicinal were extracted based on the analysis of 253 cases of prescriptions by TCM inheritance Platform System. The frequent-used herbs were analyzed. Twenty-eight main combinations and 14 new prescriptions were extracted. Conclusion: The complex combination rules of medicinal in prescriptions for liver cirrhosis due to chronic hepatitis B collected in CNKI have been clarified by TCM inheritance Platform System, which is helpful to study the treatment of Chinese TCM for liver cirrhosis due to chronic hepatitis B.