This paper is to summarize medicinal combination rules for treating lumbago with the data of “Dictionary of Chinese Medicine Formula” (first version). 558 formulas were analyzed via the software, Traditional Chinese Medicine Inheritance Support System (TCMISS). Qi-tonifying medicinal are most commonly-used combined with pathogen eliminating medicinal and stasis-removing medicinal. It reflects that the most possible cause of lumbago is deficiency of vital qi as the root cause and external pathogens and blood stasis as the sthenia pathogenic factors. By dynasty classification analysis, it is found that warming and obstruction-removing is the major therapeutic method before Song dynasty, tonifying kidney and dispelling dampness are equally important in the Jin and Yuan period, and tonifying occupied a more important position after Ming dynasty. Therefore, it is showed a process of continuous development of lumbago formulas. Clearing the thoughts from dynasty evolution about lumbago formula development is helpful to develop summarized therapeutic methods and provide valuable references for the treatment of lumbago.