Prevention and treatment of tumor metastasis is the focus of tumor research nowadays and more attention is attached in the improvement of premetastatic niche.But Chinese Medicine theory and therapeutic strategies of premetastatic niche are not sufficient up to now.More studies of modern medicine research and practice should be performed to assist the prevention and treatment of tumor metastasis via Chinese medicine.This paper discussed the strategy of Chinese medicine treatment in improvement of premetastatic niche based on the theory of ascending and descending of qi transformation combined with professor Hua Baojin′s tumor treatment experience of and molecular mechanism of premetastatic niche so as to innovate the therapy mode of tumor and provide a reference for Chinese medicine treatment of tumor metastasis.