This passage summarized and analyzed the effective ingredients of treating Alzheimer’s disease of Fufang yizhi granule by literature research. The results showed that ginsenosideRb1, Rd, Re, Rg1, Rg2, Rg3 of Panax ginseng C.A. may have inhibition effect on the nerve cell toxicity caused by protein Aβ by different molecular mechanism; notoginsenosideR1, R2, R4, R6, Fa could relieve cell response to neurotoxicity of Aβ, and promote the outgrowth of neurites, have antagonism on the pathological development of Alzheimer’s disease; Gynostemma saponins III, IV, Ⅻ, X,Ⅰ, A-AH could obviously enhance the ability of learning and memory of mouse, improve the function of the hippocampus cholinergic system, and had the protection effect in AD cell model induced by Aβ; icariin had the protection effect in AD cell model induced by Aβ, which benefited for the treatment of AD; protocatechuic acid, mulberry anthocyanins, oxyresveratrol had the good protection effect on nervous system. The results of the study suggest that saponins and flavonoid are the main ingredients of Fufang yizhi Granule for treating Alzheimer’s disease, which lays as foundation for the further study of this product on the material basis.