To study the effect of the five Alpinia Rox(Alpinia officinarum Hance, Alpinia galangal(L.)willed, Alpinia katsumadai Hayata, Alpinia galangal, Alpinia oxyphyllaMiq) on cyclie Adenosine monnphosphate (cAMP) levels, cyclie guanosine monophosphate (cGMP) levels, and ratio of cAMP/cGMP in stomach excessive cold syndrome rats. Methods:Rats were divided into blank control group, model group, 2 positive control group, and 10 warm-heat herb groups, with 10 rats in each group. Rats model of stomach excess-cold syndrome was established by intragastric infusion of the 15% glacial acetic acid and 4 ℃ Common Anemarrhena Rhizome decoction liquid. After establishing the model, blank group and model group were given water, warm-heat herb respectively. The contents of cAMP, cGMP of stomach tissue, serum, vascular smooth muscle platelet were detected by the method of enzyme-linked immunoassay. Meanwhile, the cAMP/cGMP ratio was calculated. Results: Compared with model group, the cAMP level of 10 subjects content in rat stomach tissue, serum,thrombocyte and vascular smooth muscle were higher (P<001,P<005); no obvious difference in cGMP content; except for low doses in Alpinia katsumadai, Galanga Galangal Seed and Alpinia oxyphylla, ratio of cAMP/cGMP in rest drug participants increased obviously (P<001,P<005). Conclusion: Five Alpinia Roxb may elevate levels of cAMP, cAMP/cGMP ratio in model rats with stomach excessive cold syndrome, which may reveal the fact that five Alpinia Roxb have the effect of warming stomach for dispelling cold.