To investigate the effect of modified Da Cheng Qi Decoction Combined with western medicine on curative effect，micro inflammation state，serum amylase and serum calcium in patients with acute pancreatitis.Methods:A total of 98 cases of acute pancreatitis were randomly divided into observation group(n=49)and control group(n=49)according to the random number table method.The observation group was treated with modified Da Cheng Qi Decoction Combined with western medicine，and the control group was treated with routine western medicine only.The course of the two groups were all 10 d.Treatment，the curative effect is compared between the two groups of patients，gastrointestinal function recovery time，WBC recovery time and hospitalization time，before and after the treatment，the plasma levels of IL-6，IL-8 and TNF-α level and serum amylase and calcium levels，and adverse reactions.Results:The total effective rate of the observation group(9184%)was higher than that of the control group(7551%)(P<005); The gastrointestinal function recovery time，WBC recovery time and hospitalization time in the observation group were better than those in the control group(P<005); After treatment，the plasma levels of IL-6，IL-8 and TNF-α were decreased in the observation group(P<005); The level of IL-6，IL-8 and TNF-α in the observation group after treatment was lower than that in the control group(P<005); The two groups after treatment of blood amylase increased，and decreased blood calcium(P<005); The observation group after treatment，serum amylase was higher than the control group，serum calcium was lower than that of control group(P<005); No serious adverse reactions occurred during the administration period.Conclusion:Modified Da Cheng Qi Decoction Combined with western medicine for the treatment of acute pancreatitis has a significant effect，can significantly improve the micro inflammatory state in patients，reduce blood calcium levels，increased serum amylase level，has the important research value.