To investigate the clinical efficacy of dysmenorrhea caused by endometriosis and the influence on the sutems as CA125、PGF2α、OT through the treatment of combination of Bushen Xuguan and activing blood circulation.Methods:The choice conforms to this topic diagnosis standard research object 80 examples stochastically divides in to the experimental group 50 examples,the comparison group 30 examples.The experimental group uses Bushen Xuguan and activing blood circulation treatment of Tradition Chinese medicine.The comparison group uses activing blood circulation treatment of Chinese medicine.Improvement of dysmenorrhea and the serums as CA125、PGF2α、OT were tested pretherapy and after treatment.Results:The total efficiency(96%)of experimental group was higher than comparison group(866%),the difference was significant(P<005).The two groups both can lower dysmenorrhea score and Jian Zheng score.Experimental group can effectively lower Jian Zheng sorce superior to comparison group(P<005).The two groups both can lower the serums as CA125、PGF2α、OT.Experimental group can effectively lower the serums as CA125、OT，superior to comparison group(P<005).Conclusion:Treatment of activing blood circulation can extenuate dysmenorrhe and Jian Zheng in Endometriosis patients,lower serums as CA125、PGF2α、OT.However the clinical efficacy of treatment of combination of Bushen Xuguan and activing blood circulation was better than treatment of activing blood circulation。So we can infer that mechanism of TMC was related with lowering the above-mentioned serums.At the same time，we can also infer that treatment of Bushen Xuguan can regulate immunity and endocrine.It is harmful to to adhesion and incursion of ectopic endometrial.Thereby it is a fundamental treatment.