In the present study,we aimed to to observe the clinical curative effect of Yuye tang in the therapy of diabetic macular edema(DME)and investigate the relationship between this effect and IL-6 and VEGF.Methods:A total of 56 patients DME were randomly divided into into 2 groups,28 patients in treatment group were treated with modified Yuye Tang and laser photocoagulation of macular,28 patients in control group were treated with only laser photocoagulation of macular.Observe visual acuity,retinal macular thickness and ocular hemodynamic situation of the two groups after treatment of 4 weeks.The expression of IL-6 and VEGF was assessed by ELISA.Results:Significant differences were observed in terms of intraocular pressure,visual acuity,retinal macular thickness and ocular hemodynamic situation(P<005).Compared with the control group,the expression of IL-6 and VEGF level in the treatment group were significantly decreased(P<005).Conclusion:Yuye Tang in the treatment of DME can effectively control the improve eyesight,retinal macular thickness and ocular hemodynamic situation,is a kind of safe and effective treatment,worthy of clinical popularization and application,adjust the IL-6 and VEGF may be Yuye Tang give play to the important targets of therapy effect.