To explore the influence of clinical indicators by Modified Xiaoke Decoction combined with metformin in treatment of patients with type T2DM of qi-deficiency and blood-stasis pattern. Methods:A hundred cases with type 2 diabetes mellitus were randomly divided into the experimental group and the control group. Patients in the experimental group were given Modified Xiaoke Decoction and metformin, while those in the control group were treated with metformin. Blood sugar, blood fat, hemorrheology, Creatinine, Urea nitrogen, Chinese medicine symptom integral and hypoglycemia and other indicators before and after the treatment were compared. Results: Relevant indexes related to blood sugar of the two groups after treatment decreased. Changes in glycemic index value of the experimental group before and after the treatment were greater than that of the control group (P<001). Blood lipids, hemorrheology, creatinine, urea nitrogen decreased in the two groups after treatment and the decrease in the experiment group were greater than that of the control group (P<001), traditional Chinese medicine symptom integral and the incidence of hypoglycemia of the two groups after treatment were decreased and the treatment group were more remarkable than the control group (P<001). Conclusion: Modified Xiaoke Decoction and metformin may significantly improve the clinical indicators such as T2DM blood sugar, blood lipid, effectively reduce diabetes complications and avoid the incidence of hypoglycemia.