To compare the effect of Duhuojisheng Decoction(DHJSD)and Qiangguhuoxue Decoction(QGHXD)，combined with Caltrate D and Xianlinggubao,on senile osteoporosis fracture.Methods:A total of 150 cases who were hospitalized from January 2013 to January 2015 were confirmed as senile osteoporosis thoracolumbar compression fractures.They were separated into three groups randomly.Group 1 were treated with Duhuojisheng decoction combined with Caltrate D and xianlinggubao； Group 2 were treated with Qiangguhuoxue decoction combined with Caltrate D and xianlinggubao； Group 3 were treated with Caltrate D and xianlinggubao.The anterior height of the 3 groups were observed before and after 2，4，8 months of treatment； the Cobb angle in the 3 groups were observed before and after 2，4，8 months of treatment； VAS score in the 3 groups were evaluated after 1,2,3,4,months of treatment； osteocalcin and bone alkaline phosphatase in group 1 and group 2 were tested before and after 2 and 4 months of treatment.The efficacy on group 3 was evaluated after 8 months of treatment.Results:In the comparison of anterior height of 3 groups，there was no obvious difference nor statistical significance before treatment(P<005)； after 2 months of treatment，the altitude lip of Group 1 was slightly lower than that of Group 2，and there was difference between the two groups(t2=20239,P<005)； after 4 and 8 months of treatment，there was no significant difference in the two groups(t4=07538，t8=05047，P>005)； after 2，4，8 months of treatment，the altitude of lip of group 3 was much higher than that of Group 1 and Group 2，thus there was significant difference(P<005).The Cobb angle measurement showed no significant difference before and after 4 months of treatment(P<005)After 2 month of treatment，the Cobb angle measurement of group 1 is significantly larger than that of group 2 and 3(P<005)； before treatment，VAS of 3 groupsshowed no significant difference(P>005)； while after 1，2，3，4 months of treatment in Group 1，VAS was much larger than that of Group 2(P<005)，and almost the same as that of group 3(P>005).Conclusion:Duhuojisheng decoction and Qiangguhuoxue decoction combined with Caltrate D and Xianlinggubao had positive effect on senile osteoporosis fracture，clinically.However，the latter onereduced the pain，induced the osteocalcin and bone alkaline phosphatase，promoted the fracture healing，inhibited bone loss and absorption and strengthened the bone.