To evaluate the effect of inducing diuresis with bland drugs in treating chronic nephritis albuminuria and its function of preventing renal fibrosis. Methods: Fifty-six patients with chronic nephritis were randomly divided into Chinese medicine (CM) group and western medicine (WM) group with 28 cases in each group. WM group was treated with losartan potassium 100 mg/d, while CM group was treated with prescription with the function of inducing diuresis combined with losartan. After 6 months treatment, 24-hour urine protein, the value of serum laminin (LN), type IV collagen (CIV), and tissue inhibitor of matrix metallo proteinase-1 (TIMP-1) were compared between the two groups. Results: 24-hour urine protein of the both groups decreased obviously after treatment compared with that before the treatmrnt (P<005). The level of LN, CIV and TIMP-1 after the treatment decreased obviously compared with those before the treatmrnt (P<005). The level of LN, CIV and TIMP-1 of CM group decreased obviously compared with those of the WM group (P<005). Conclusion: Treatment of inducing diuresis with bland drugs may reduce 24-hour urine protein effectively compared with western medicine and possibly prevent fibrosis of kidney interstitium.