To observe the effect of andrographolide total ester sulfonate on inflammatory factors in serum of patients with sepsis in different periods and to explore new methods of diagnosis and treatment of sepsis.Methods:There were 80 cases of sepsis meeting the criteria, who were hospitalized in respiratory department, respiratory ICU, emergency department, digestive department, ICU and other departments of Lanzhou General Hospital of Lanzhou Military Command from December 2013 to March 2015, divided into sepsis group and severe sepsis group according to their condition. Each group were randomized into sub treatment group and sub control group, each 20 people, and on the day of admission, 3 days and 7 days after treatment, all patients’ PCT, IL-6, CRP and HsCRP in serum were tested.Results:The Basic information and Inflammatory facotrs concentration before treatment were compared in sepsis group, severe sepsis sub treatment group and sub control group (P>005); it showed statistical significance in the comparison of PCT,IL-6 and HsCRP level between various periods before and after the treatment (P<005); in sub treatment group and sub control group, patients’ CRP level before treatment was compared with that of 3 days after treatment (P<005), and the difference was statistically significant, while that of 3 day and 7 days after treatment in both groups were also compared (P>005), there was no statistical significance.IL-6, PCT and CRP concentration of severe sepsis sub treatment group before and after treatment 3 days were compared(P<005), showing no statistical significance when HsCRP in the sub control group and sub treatment group of various period was compared (P>005).Conclusion:Andrographolide total ester sulfonate had great effect on reducing inflammatory factors concentration like IL-6, HsCRP, PCT and CRP in sepsis and severe sepsis patients of early stage, thun it could be used as treatment of sepsis theoretically.