To analyze the effect and safety of self-made Heat-clearing and Detoxicating, Blood-activating and Stasis-resolving Formula combined with Cinobufotalin in damp heat and toxin type of cervical carcinoma.Methods:A total of 68 patients with damp heat and toxin type of cervical carcinoma were randomly divided into observation group and control group, with 34 cases in each groups. The patients were treated with radiation and chemotherapy and surgery. Observation group added with Heat-clearing and Detoxicating, Blood-activating and Stasis-resolving Formula combined with Cinobufotalin. The clinical curative effect and adverse reactions were observed between the two groups.Results:The total effective rate of the observing group was 852%, control group 705%, which had no statistical significance (P>005). The differences between the two groups in nausea and vomiting, liver and kidney damage, loss of hair, neurotoxicity, and a lower incidence of adverse reactions such as electrolyte disorder were statistically significant different (P<005).Conclusion:Heat-clearing and Detoxicating, Blood-activating and Stasis-resolving Formula combined with Cinobufotalin in damp heat and toxin type of cervical carcinoma has clinical curative effect of high satisfaction, with less adverse reaction.