To observe the efficacy of Yangxin Tablets on patients with unstable angina and its influence on serum lipids and homocysteine levels.Methods:The patients were randomly divided into a control group and a treatment group, with 30 cases in each. The control group were given routine treatment of western medicine, while patients in the treatment group with 30 cases were treated with routine therapy combined with Yangxin Tablets. Two groups were treated for 28 days. Clinical efficacy of two groups, levels of serum lipid and Hcy were observed.Results:After treatment, clinical and electrocardiographic effects in treatment group were higher than those of the control group (P<005). Serum lipids and Hcy of two groups were improved (P<005 orP<001), while improvement of the treatment group were better than that of the control group(P<005).Conclusion:Yangxin Tablet has a reliable clinical therapeutic effect on unstable angina, which improved myocardial blood supply, regulated blood lipids, developed blood vessel endothelial function and stabilized vulnerable atherosclerotic plaque.