To evaluate the effects of YangXinShi tablets on coronary heart disease angina pectoris complicated with depression.Methods:A total of 90 patients who were diagnosed as coronary heart disease angina pectoris complicated with depression in the hospital were collected. All patients were randomly divided into YangXinShi group and control group, 45 cases in each group. The control group is on the western medicine (conventional western medicine treatment) treatment basis and the YangXinShi group was given oral administration of YangXinShi tablets and the mentioned western medicine treatment. After 12 weeks’ treatment, the clinical symptoms of angina pectoris, LVEF, hs-CRP, NT-proBNP, HAMD and adverse reactions of all patients were detected.Results:After treatment, 1) the total effective rate of improving angina pectoris in YangXinShi group (9778%) was significantly higher than that of the control group (8000%) and the difference was statistically significant (P<005); 2) the LVEF in YangXinShi group (58±66)%) was significantly higher than that of the control group (53±44)%，P<005; 3) the hs-CRP in YangXinShi group (137±036) mg/L was significantly lower than that of the control group (173±042) mg/L,P<005; 4) the NT-proBNP in YangXinShi group (687±133)ng/L was significantly lower than that of in control group (970±115)ng/L，P<005; 5) the HAMD average score in YangXinShi group (65±17) was significantly lower, comparing with that of in control group (107±19),P<005; 6) the incidence of adverse reactions in YangXinShi group (222%) was significantly lower than that of the control group (1333%),P<005Conclusion:YangXinShi tablets combined with western medicine on coronary heart disease angina pectoris complicated with depression was better than the conventional western medicine treatment.