To evaluate the clinical toxicity and efficacy of Fufanghongdoushan capsule combined with γ-ray Body Stereotactic Radiation Therapy in treatment of locally advanced pancreatic cancer. Methods: A total of 45 patients with locally advanced pancreatic cancer were randomized into two groups. The combination group received γ-ray Stereotactic Body Radiation Therapy which was given isodose curve of 50%～60%, tumor encircling dose of 30～45 Gy per fraction, 10～11 fractions. Combined with Fufanghongdoushan capsule 06 g，three times a day for consecutive 21 days for six courses. And the control group was with γ-ray Stereotactic Body Radiation Therapy only. Toxicities and effects were evaluated according to the criteria of WHO and RTOG. Results: The CR in combination group and control group were 286% and 185% respectively(P>005). Response rate of combination group was 821% and 741% in control group(P>005). Two groups of the median progression-free surial (PFS) were 10 months and 6 months respectively; The rate of gastrointestinal tract side reaction in combination group and control group were 826% and 682%，myelosuppression in combination group and control group were 783% and 636%，respectively. Conclusion: Fufanghongdoushan capsule combined with body gamma system treatment can improve local control rate and effective rate for inoperable patients with local advanced pancreatic carcinoma, and adverse reaction is well tolerated.