To discuss the effect of Ginseng and Poria Stomach Capsule on gastrointestinal reaction and inflammatory factor levels of peripheral blood in patients with breast cancer in chemotherapy period.Methods:A total of 132 patients with breast cancer were selected and divided randomly into capsule group and control group，66 in each group.The control group patients received Azasetron(10 mg/time，1 / d，intravenous infusion given for 7 days after chemotherapy)，capsule group patients received Ginseng and Poria Stomach Capsule(2 pills /time，3 times/d，to oral taken for 7 days after chemotherapy).The enzyme-linked immunosorbent method was used to detect the C-reactive protein(CRP)，tumor necrosis factor-α(TNF-α)，interleukin 6(IL-6)level of peripheral blood of all patients after the treatment.Results:Curative effect of the capsule group was significantly higher than the control group(P<005)； After treatment，the peripheral blood CRP，TNF alpha，IL-6 levels of the capsule group were significantly lower than the control group(P<005)； The gastrointestinal adverse reactions of the capsule group were significantly lower than the control group(P<005).Conclusion:Ginseng and Poria Stomach Capsule can effectively reduce the gastrointestinal adverse reaction of breast cancer patients in chemotherapy period，and reduce the body’s inflammatory response，improve the patient’s tolerance，which is conducive to the smooth completion of chemotherapy and improvement of the curative effect.