To analyze the curative effect of Shenqi Powder combined with TP scheme in advanced non-small cell lung cancer patients and its effect on immune function.Methods:Eighty cases of advanced non-small cell lung cancer patients were selected as the research objects and divide into control group and treatment group by single blind method (n=40). Patients in control group received TP chemotherapy treatment and patients in the treatment group received Shenqi Powder and TP scheme in advanced non-small cell lung cancer patients.Results:The quality of life scores of the control group before and after the treatment showed no significant difference (t＝0461, P＝0461). There was a significant difference of quality of life scores in the treatment group before and after the treatment (t＝34420, P<0001). CD4+ cells and CD4+/CD8+ (t＝2805, P＝0006) of the control group before and after treatment showed obviously significant differences, while CD8+ cells showed no difference (t＝1608, P＝0019). CD4+ cells (t＝2122, P＝0037), CD8+ cells (t＝2393, P＝0019) and CD4+/CD8+ of (t＝-4667, P<0001) of the treatment group after treatment indicated significant difference. CD4+ cells (t＝2701, P＝0008), CD8+ cells (t＝2805, P＝0006) and CD4+/CD8+ between the control group and the treatment group after treatment indicated significant difference. The number of patients with nausea and vomiting after treatment showed significant difference between the control group and treatment group (χ2=8584, P＝0003) and the number of abnormal peripheral nervous sensation also showed significant difference (χ2=6270, P＝0012).Conclusion:Shenqi Powder combined with TP scheme for patients with advanced non-small cell lung cancer may better relieve the patient’s clinical symptoms, improve quality of life, reduce adverse reactions, prolong survival and enhance the patient’s immune function.