To observe and evaluate the effect of Three Ginseng and Guiqi Mixture in the treatment of coronary heart disease and heart failure as well as its effect on NT-proBNP level. Methods: Total 100 patients with coronary heart disease and heart failure in our hospital from January 2013 to February 2015 were randomly divided into observation group (50 patients were treated with Three Ginseng and Guiqi Mixture on the basis of the control group) and control group (50 patients were simply treated with conventional western medicine). Comparative analysis of two groups’ patients on syndrome of Chinese medicine, cardiac function, quality of life in Minnesota survey points, NT-proBNP levels were performed. Results: The syndrome of Chinese medicine and Cardiac function effect in observation group were better than the control group, the differences were statistically significant (P<001). Minnesota survey of quality of life score of the observation groups was significantly lower than the control group, the difference was statistically significant (P<001); plasma NT proBNP levels of the observation group were significantly lower than those in the control group, the difference was statistically significant (P<001). Conclusion: Three Ginseng and Guiqi Mixture has significant effect in the treatment of patients with coronary heart disease and heart failure. It can reduce NT-proBNP level of patients and improve the quality of life of patients.