To investigate the effects of Erbuzhuyu Decoction on endometrium receptivity of rats model with embryo implantation dysfunction. Methods:Rats model with embryo implantation dysfunction was prepared for the study on expression changes of endometrial SCFmRNA, HOXA-10 mRNA, LIF, ER, PR and ανβ3. Results: GnRHa+, HMG+, HCG scheme may reduce the endometrium receptivity, and Erbu Zhuyu Decoction may regulate regulate the expression of relevant regulating factors in networks of rat endometrial microenvironment to improve endometrium receptivity. Conclusion: Erbu Zhuyu Decoction is bound to have the effect on endometrium receptivity and its activity pathway is multi-targeted and multi-linked.