To investigate the gastrodin’s effect on blood pressure，vascular protective effect and mechanism of oxidative stress in hypertensive rats.Methods:A total of 50 rats were randomly divided into normal control group，model group，telmisartan group，gastrodin low dose group，high dose group，10 rats in each group.The normal control group were given the same dose of normal saline，model group given dose of normal saline after modeling，telmisartan group 5 mg/(kg-D)by gavage after modeling，gastrodin low dose group 40 mg/(kg-D)by gavage，high dose group 160 mg/(kg-D)by gavage.Rats in each group were administered orally for 8 weeks，once a day.Results:Compared with the model group，systolic blood pressure of telmisartan group and gastrodin in each dose group dropped(P<005)； compared with telmisartan group，gastrodin high-dose group’s systolic blood pressure rose(P<005)，gastrodin low-dose group’s systolic blood pressure dropped(P<005)； gastrodin high dose group’s systolic pressure was significantly lower than that of the low dose group(P<005)； compared with the model group，telmisartan group and gastrodin group’s ET-1 content dropped，while the content of NO increased(P<005)； compared with telmisartan group，high dose group’s content of ET-1 dropped and the content of NO increased(P<005)，and the gastrodin low dose group ET-1 content increased and the content of NO dropped(P<005)； gastrodin high dose group’s ET-1 was lower than that of low dose group，and NO content was higher than the low dose group(P<005)； compared with the model group，SOD and MDA of telmisartan group and gastrodin each dose group dropped(P<005)； compared with telmisartan group，SOD and MDA dropped in high dose group(P<005)； the content of SOD and MDA of gastrodin in high dose group were lower than that of gastrodin low dose group(P<005).Conclusion:After using gastrodin，the blood pressure of hypertensive rats can be dropped obviously，and the protective effect of the blood vessel and the anti lipid peroxidation damage can be achieved，which is worth further study.