Terms, as “multiple sclerosis”, “acupuncture”, “Chinese medicine” and “demyelinating disease” were adopted for research and only peer-reviewed journal articles was collected and articles with acupuncture treatment included in Chinese medicine treatment was also omitted. The MEDLINE, nursing and allied health literature accumulation index and Ovid alliance complementary medicine library, and acupuncture textbooks were all included for the research. ifteen articles meeting the standards were searched. Five of them were about the effect of acupuncture on quality of life (Quality of Life scale, QLS), three articles were for the effect of acupuncture on fatigue due to multiple sclerosis (MS), two for acupuncture treatment studies on MS spasm, two for the study of acupuncture treatment on pain after MS, and three articles were about animal studies. Despite the various evidences showed that acupuncture is effective for MS, but literatures on the use of acupuncture and the efficacy of acupuncture are still few and most of the studies have certain methodological defects.