The prescription of Xiaojin Capsule was originated in “Waike Zhengzhi Quanshengji”, written by Wang Hongxu in Qing Dynasty and then developed by Jianmin Group. As its effective composition can be dissolved and absorbed quickly, the product has good curative effect with low ADR rate. Many years of clinical researches have shown that the product has good treatment effects on thyroid nodules, hyperplasia of mammary glands, sequelae of PID, endometriosis of uterus, fibroid, chloasma, chronic epididymitis, etc. The clinical application of Xiaojin capsule in these carbuncle syndromes were reviewed in this paper to provide references for further mining in other applications.