Zhang Zhongjing used thecombined therapy of cooling and warmingskillfully in Treatise on Cold Damage Diseases.He established a paradigm of this combined therapy，including relieving exterior-interior syndrome，harmonizingmiddle energizer，clearing upper heat and warming lower cold，and combined supplementing of yin and yang，by identifying the specific region and primary and secondary of cold and heat.There were lots of formulas involving the combined therapy of cooling and warming in Treatise on Cold Damage Diseases.In these relevant formulas，the application of herbal medicine based on syndrome differentiationand decocting and taking methods was accurate and ingenious，reflecting the preciseness and flexibility of Zhang Zhongjing in syndrome differentiation and treatment.The author chose some classics formulas using thecombined therapy of cooling and warming from Treatise on Cold Damage Diseases to conclude and discuss the application features of this combined therapy from five main aspects.