To observe the clinical efficacy of Lianghe Decoction in treating insomnia patients with stagnation of liver qi and yin deficiency. Methods:A total of 42 insomnia patients with stagnation of liver qi and yin deficiency syndrome were divided into two groups according to the random number table, each group having 21 patients. The treatment group was given Lianghe Decoction, while the control group was given Celestial Emperor Heart-Tonifying Decoction. After four weeks’treatment, the Pittsburgh Sleep Quality Index score(PSQI) and the TCM (traditional Chinese medicine) Syndromes Scale were evaluated. Results:PSQI in the two groups both dropped after four weeks’treatment while there were significant differences in the overall evaluation between the two groups (P<0.05). The treatment group had better results than the control group; TCM Syndromes Scale in the two groups showed significant differences after four weeks’treatment (P<0.05) while there were significantly better results in the treatment group (P<0.05). Some syndromes like difficulty in falling asleep and waking up easily in treatment group were improved. There were no adverse effects in both two groups, which showed the two decoctions were safe. Conclusion:The clinical efficacy of Lianghe Decoction in treating insomnia patients with stagnation of liver qi and yin deficiency is clear and safe, which is worthy of clinical promotion.