To investigate the development of the prognosis of patients with deep venous thrombosis after closed fracture of lower limb and the change of the blood clot elastic diagram. Methods:Lower limb closed fractures 68 cases during January 2014 to December 2015 in our hospital were selected randomly. And they were treated by open reduction and internal fixation and confirmed to be in hypercoagulable state, including 21 cases of female, 47 male, aged 20～70, mean age (51.42±6.06). They were randomly divided into treatment group and control group, 34 cases in each group, two groups were given conventional open reduction and internal fixation and orthopaedic basic treatment, while the control group was treated with 1 000u low molecular heparin and antiplatelet activity drug treatment, the treatment group were given oral Tongmai Decoction. Plasma prothrombin time (PT), activated partial prothrombin time (APTT), platelet count and thrombelastograph (TEG) were measured before the treatment and after 7th days and 14th days’treatment respectively. Results:After the intervention, the 7 d and 14 d PT, APTT and TEG were improved significantly in both two groups(P<0.05), no significant differences were found between the two groups (P>0.05). Conclusion:Tongmai Decoction can effectively improve the blood coagulation state, which is an effective treatment of deep venous thrombosis.