To discuss the effect of Ginseng and Astragalus Qi-Replenishing Drop Pill on early diabetic nephropathy patients’serum amyloid protein(SSA), interleukin 6 (IL-6) and tumor necrosis factor-α (TNF-α) levels. Methods:Early diabetic nephropathy 100 patients were retrospectively analyzed from September 2012 to December 2015 in our Hospitals. According to the treatment, all patients were divided into pill group and control group, 50 cases in each group, control group patients were given regular diet control, insulin hypoglycemic therapy. On its basis, the pill group were given 500 mg of Ginseng and Astragalus Qi-Replenishing Drop Pill. The enzyme-linked immunosorbent (ELISA) was used to detect serum SSA, IL-6 and TNF-α level, followed up for 6 months. All patients’index levels, before and after treatment 1, 3, 6 months’urine beta 2 microglobulin (β2-MG), urinary albumin excretion rate (UAER) and adverse reactions were observed. Results:After the treatment, the pill group’s serum SSA, IL-6 and TNF-α level were significantly lower than the control group (P<0.05); Pill group patients’1, 3, 6 months β2-MG, UAER levels were significantly lower than the control group (P<0.05); Pill group and control group had no adverse reactions. Conclusion:Ginseng and Astragalus Qi-Replenishing Drop Pill can effectively improve the inflammatory state in patients with early diabetic nephropathy, reduce the excretion of urine albumin of patients with safety, which is worthy of further clinical promotion.