To observe the clinical curative effect of Snakegourd Fruit Injection on wind-phlegm obstructing collateral type stroke and its mechanism analysis. Methods:A total of 70 cases of patients of inpatients and outpatients in our hospital with stroke phlegm type were randomly selected, including 21 cases of female, 49 male; And they s were randomly divided to treatment group (35 cases), control group (35 cases), two groups of patients were given conventional medical therapy and control group was also given edaravone treatment; and treatment group Snakegourd Fruit injection treatment. Patients in the two groups were treated for 4 weeks, and then evaluate the activities of daily living (ADL), clinical neural function defect score standard (CSS) before and after treatment, plasma endothelin in patients with endothelin-1 (ET-1), at the same time and correlation analysis. Results:After 4 weeks’treatment, the treatment group’s effective rate was significantly higher than that of the control group (P<0.05), compared with before treatment, patients’ET-1, ADL, CSS scores in the two groups improved significantly (P<0.05), But apart from the ADL score, the treatment group’s ET-1, CSS score had no significant improvement compared with the control group (P>0.05). Conclusion:Snakegourd Fruit Injection can improve the wind-phlegm obstructing collateral type stroke patients with safe and effective clinical outcome.