To investigate the clinical efficacy of insulin associated with Chinese yam diet therapy on diabetes. Methods:Select 98 cases of type 2 diabetes outpatients who received treatment in our hospital from January 2014 to December 2015, and divide them into a study group and a control group randomly. Both of the two groups of patients were treated with insulin to control blood sugar, while the study group were also provided with yam diet, comparing the efficacy and fasting plasma glucose (FPG), 2 h postprandial blood glucose (2 hPG), glycated hemoglobin (HbA1c), fasting C peptide（FCP）、C peptide 2 hours after meal(2 hCP)、improved insulin resistance index（HOMA-IR）,improved islet function index（HOMA-islet）,total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL), high density lipoprotein cholesterol (HDL) levels of both groups before and after the treatment. Results:Patients total effective rate (95.92%) of the study group was significantly higher than that of the control group(75.51%) with statistical significance（P<0.05）. Good rate of development in TCM syndromes in the study group (93.88%) was considerably higher than that of the control group (75.51%), showing statistical significance as well（P<0.05）. Patients’FPG、2 hPG、HbA1c、HOMA-IR、HOMA-islet、TC、 TG、LDL、HDL levels before treatment were compared， with no statistical significance （P>0.05）; After the treatment, FPG, 2 hPG, HbA1c, HOMA-IR, TC, TG, LDL levels of patients in the study group were all lower than those of the control group, while HDL、FCP 、2 hCP、HOMA-islet levels higher（P<0.05）with statistical significance. Conclusion:Insulin associated with Chinese yam diet therapy treatment on diabetes is the integration of Chinese and Western medicine and effectively regulates blood sugar and blood lipids and improves islet function，thus develops clinical efficacy .