To explore the efficacy of Xiao Chuan paste point application in the treatment of patients with stable chronic obstructive pulmonary disease (COPD) and influence on airway inflammation. Methods:All 67 cases of stationary phase COPD patients were randomly divided into a control group (n=33) and an observation group (n=34), which were treated with Placebo and Xiao Chuan paste point application respectively, 3 times in summer dog days, and for 2 years continuously. The TCM clinical symptoms efficacy and TCM syndrome integral before and after treatment were counted. The index of lung function detected with lung function detector before and one, two years after treatment. Induced sputum sample of 2 groups before and six months after point application were collected, detecting the content of inflammatory cells and inflammatory factors. Attack of cold and acute episodes during treatment of 2 groups were counted.Results:The rate of TCM clinical symptoms efficacy of observation group was 85.29%, which was higher than that of control group, 63.64%, (P<0.05). Compared with that before treatment, the TCM syndrome integral of observation group decreased significantly 1 and 2years after treatment (P<0.01), which was greatly lower than that of control group ( P<0.05 or P<0.01). The FEV1, FEV1/PR and FEV1/FVC of observation group improved after 2 years’treatment, compared with that before treatment (P<0.05), but there was no significant difference (P>0.05). The proportion of neutrophils, IL-8 and LEP levels of induced sputum supernatant in observation group decreased significantly after treatment (P<0.01), while sIgA levels increased and was significantly higher than that of the control group(P<0.01), and there were significant difference between 2 groups (P<0.01). There were no obvious change in the proportion of neutrophils, IL-8, LEP and sIgA levels in control group (P>0.05). The average frequency of cold, acute attack, emergency treatment and hospitalization in observation group decreased, which were lower than that of control group (P<0.05 or P<0.01). Conclusion:Xiao Chuan paste point application improves the lung function of stationary phase COPD patients, alleviates the airway local inflammation, strengthens airway mucosal protective effect, and reduces the later average annual frequency of acute attack.