To observe the clinical effect of Furong Ointment in treating the acute oncotic ulcer by external application．Methods:One hundred and forty-nine cases of outpatient acute oncotic ulcer were randomly divided into a study group and a control group．The study group were treated with Furong Ointment, control group Mupirocin Ointment, in the infected places externally and evenly. Overall curative effect and symptoms and signs were graded respectively in the 2 groups before and after treatment, using SPSS analysis the curative effect．Results:The opening sore of red area of the two groups had significant difference，but other symptoms and signs of the two groups had no significant difference．In terms of overall curative effect，the control group’s effective rate was 92.21%，and the study group’s effective rate was 97.22%，while the chi-square was 6.42，P=0.0929，suggesting that the two groups have no significant statistical differences．Conclusion:Furong Ointment has a fine clinical effect in treating acute oncotic ulcer by the external application．