To explore clinical effect of Xiaoer Huadusan combined with Licorzine Granules therapy children with herpangina.Methods:A total of 133 patients who were selected with hand-food-mouth disease,and observed clinical symptoms.Xiaoer Hnadusan in combined with Licorzine Granules thempy in observation group,and fibavirin effervescent Granules thempy in routine group.Effects of treatment were evaluated,and statistical analysis.Results:Observation group and routine group in children with thermal annealing time,no difference between groups(P>0.05);But the observation group of pharyngeal herpes disappear time and short time of sore throat in children with eating the routine group,the difference statistically significant(P<0.05).Conclusion:XiaoerHuadusan combined with Licorzine Granules therapy herpangina,has a goodtherapeutic effect,can be a reference for clinical treatment.