To evaluate the effects of YangXinShi tablet oncoronary heart disease complicated with diabetes.Methods:A total of 100 patients who were diagnosed as coronary heart disease complicated with diabetes in the hospital were collected.All patients were randomly divided into YangXinShi group and control group，50 cases in each group.The control group on the western medicine(western medicine treatment)treatment basis and the YangXinShi group given oral administration of YangXinShi tableton the basis of the treatment in the control.After 6 months treatment，the clinical symptoms of angina pectoris，blood glucose，HbA1c，LVEF，hs-CRP，NT-proBNP，Hcy and adverse reactions of all patients were detected.Results:After treatment，1)the total effective rate of improving angina pectoris in YangXinShi group(92.00%)was significantly higher than that of in control group(82.00%)and the difference was statistically significant(P<0.05); 2)the fasting plasma glucose，two hourspostprandial glucose and HbA1c in YangXinShi group(5.3±1.1)mmol/L、(9.2±1.8)mmol/L and(5.6±0.5)% were significantly lower than that of in control group (6.1±1.5)mmol/L、(10.4±2.1)mmol/L and(6.1±0.8)%，P<0.05; 3)the hs-CRP in YangXinShi group (1.21±0.22)mg/L was significantly lower than that of in control group (1.53±0.43)mg/L,P<0.05; 4)the NT-proBNP in YangXinShi group (667±145)ng/L was significantly lower than that of in control group (927±136)ng/L，P<0.05; 5)the Hcy in YangXinShi group (8.64±0.47)μmol/L was significantly lower than that of in control group (9.88±0.39)μmol/L，P<0.05; 6)the incidence of adverse reactions in YangXinShi group(2.00%)was significantly lower than that of in control group(18.00%)，P<0.05.Conclusion:YangXinShi tablet combined with western medicineon coronary heart disease complicated with diabetes was better than the conventional western medicine treatment.