To investigate efficacy of tonifying qi, softening hardness and eliminating abdominal mass method (Erjiaxiaozheng decoction) on treatment of idiopathic pulmonary fibrosis with qi deficiency and blood stasis. Methods:Collecting 49 cases of IPF from January 2015 to December 2016,we divided all the patients into two groups:the treatment group (treated with Erjiaxiaozheng decoction)，and the control group (treated with Acetylcysteine).Thus we mainly observed and assessed such indexes as St George’s respiratory questionnaire scores, 6-minute walking distance, Chinese medicine symptom scores and high resolution CT scores before treatment, 3 months after treatment and another later 3 months of following up. Results:Data above were evaluated:in treatment group, St George’s respiratory questionnaire scores, 6-minute walking distance, Chinese symptom scores of 3 months after treatment and after another later 3 months of following up showed statistical difference (P<0.05); in the control group, 6WMD before treatment, 3 months after treatment and after another later 3 months of following up showed statistical difference (P<0.05), while others did not (P>0.05). And there was no statistical difference in High Resolution CT between two groups. Conclusion:Erjixiozheng decoction can improve life of idiopathic pulmonary fibrosis with qi deficiency and blood stasis patients, eliminate Chinese medical symptoms with long-time efficacy, which is better than control group. Both of the two groups increased 6MWD, treatment group better but does not last.