To explore the clinical curative effect and mechanism of Fuzhengkangai decoction in stomach cancer.Methods:Fourty-one patients with gastric cancer were randomly divided into two groups, all given Docetaxel 40 mg/m2, on the first and the eighth day intravenous drip for1 h, and an allergy conventional pretreatment；Oxaliplatin 75 mg/m2, 1 day, intravenous drip for 2 h；21 d as a cycle, and there were two chemotherapy cycles. The 21 cases of Control group were provided with extra placebos; The 20 cases of Treatment group were on the basis of above treatment and with Fuzhengkangai decoction for 1 course (40 d). Curative effect, clinical symptoms, symptom integral, adverse reactions, and immune index, etc. were observed.Results:The total effective rate of the observation group was significantly higher than that of the control group (P<0.05), and the related parameters of immune function was better than that of control group (P<0.05), KPS score (carr’s quality of life score) also better (P<0.05).Conclusion:The consequence of Fuzhengkangai decoction combined with western medicine in stomach cancer which is due to liver-stomach disharmony is favorable with no serious adverse reactions, and can significantly improve the immune function and survival condition, whih is worthy of promotion.