To establish complex models with allergic rhinitis of kidney-yang-deficiency by three different kidney-Yang-deficiency inducers, glucocorticoid, hydroxyurea and adenine, based on guinea pig models of allergic rhinitis sensitized by ovalbumin, for screening a reliable and ideal model of allergic rhinitis of kidney yang deficiency pattern. Methods: Guinea pig models of Allergic Rhinitis sensitized by ovalbumin were set and glucocorticoid, hydroxyurea or adenine was used to build the complex models of allergic rhinitis with kidney-yang deficiency. The macro signs, death and partial allergy symptoms of animals were observed, the serum sIgE and histamine were tested by ELISA (enzyme-linked immunosorbent assay) and the morphology change of kidney and testis tissue were observed by HE (hematoxylin-eosin) staining. Results: Three different Yang deficiency inducers, glucocorticoid, hydroxyurea and adenine, could lead to kidney-yang-deficiency symptoms and signs, weight loss, and cause certain death. Compared with the control group, it is found the affection on morphology of glucocorticoid to kidney and testis tissue was little, while which of hydroxyurea and adenine were great. Conclusion: By comparison of three different complex models with allergic rhinitis of kidney-yang deficiency, the model induced by hydroxyurea was more stable and suitable with lower death rate. More researches should be conducted for the evaluation criteria of the allergic rhinitis animal model.