Abstract:To investigate the effect of lignum sappan with different tonifying drugs on growth and metastasis of Lewis lung cancer(LLC).Methods:Lewis lung carcinoma C57BL / 6 mouse tumor models were randomly divided into six groups: the control group,lignum sappan group,lignum sappan+astragalus group,lignum sappan+Angelica group, lignum sappan+Aconite group,lignum sappan+Liriope group.Continuous oral administration 21 days.Mice were sacrificed on the 21th day.Inhibition rate and suppressing metastasis rate were observed.Results:lignum sappan with different tonifying drugs could inhibit the growth and metastases of LLC (P<0.05), lignum sappan+Angelica sinensis group, lignum sappan+Liriope group, lignum sappan+Aconite group were better than lignum sappan group.(P<0.05).Conclusion:Drugs compatibility of lignum sappan with tonifying drugs and could inhibit tumor growth and metastasis.