In recent years，with the improvement of living standards，the incidence of non-alcoholic steatohepatitis(NASH)is increasing.NASH may affect the progression of others chronic liver disease.NASH and metabolic syndrome interact with each other.As the pathogenesis is still poorly understood，there is no effective prevention and control measures so far.In this paper，the main literature in China and abroad during the past five years was collected and understanding and the development research of NASH’s pathogenesis were reviewed.