Diabetes Mellitus，diabetic kidney disease and nephrotic syndrome are all common in department of nephrology and endocrinology，and there are certain relation among diabetes and diabetic kidney disease，diabetic kidney disease and nephrotic syndrome in terms of pathogenesis，therapy，clinical manifestation etc.In this article，we discussed the characteristics of the prescriptions that Professor Lyu Renhe made to treat the three diseases by drug frequency.It also embodies the thought of “making the past serve the present and foreign things serve China” and the therapeutic features of “treating disease due to disease principle”.And the medication has a significant clinical efficacy.