To evaluate the effect of combined external therapy of Traditional Chinese Medicine on advanced non-small-cell lung cancer (NSCLC) and body′s immunity. Methods:Sixty cases of Ⅲb-Ⅳ NSCLC patients were collected to observe the differences in the TCM symptoms and peripheral blood T lymphocyte level between people included in pathway and not include. Results:After treatment, TCM symptom scores were lower than before treatment in both groups, and the scores of patients treated with pathway is significantly lower than that of patients not included in pathway (P<0.05). After treatment, CD8+ CD28+ both increased in the two groups, and in the treatment group, the level was obviously higher than before treatment, also higher than the control group (P<0.05). Conclusion:Combined external treatment of traditional Chinese medicine can effectively improve clinical symptoms in patients with advanced NSCLS, and also can improve their anti-tumor ability by improving immuntility.