To investigate the efficacy of treatment of integrated Chinese medicine and western medicine in thrombosis obliterans of second stage or above.Methods:A total of 54 patients with TO above the second stage during July in 2012 to March in 2016 in our hospital were given antiplatelet drugs (aspirin) as well as vasodilators (alprostadil) and antibiotic treatment.According to different symptoms and signs，all the cases were divided into four TCM types (cold deficiency; sluggish; heat toxicity; deficiency of both qi and blood)，and corresponding treatments were given based on the syndrome differentiation.External Chinese medicine and debriding treatment were also given to local tissue ulceration.Results:The mean hospital duration of all the cases was 37.5 days.Two cases of 9 patients with gangrene received high amputation due to deterioration of ischemic symptom，three cases of digits showed dry gangrene and fall off on their own，42 cases′ pain had been improved at different levels in hospital，12 cases′ pain had no obvious improvement.And 15 cases of 38 ulcer recovered，15 cases had reduced ulcer area，8 cases had no improvement in ulcer.When discharged from hospital,17 cases were cured，13 cases were effective，17 cases showed improvement，7 cases had no effect.The total effective rate was 87.1%.Conclusion:Integrated Chinese medicine and western medicine treatment has good effect in thrombosis obliterans.